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Figures 1B , 3 ), resulting in down-regulation of the hepatic GHR expression, as inferred from reductions in circulating levels of GHBP ( In the setting of chronic inflammatory disease states (e.g., Crohn’s disease or juvenile chronic arthritis), these diseases can also disturb the physiological synergy of the GH/IGF-I axis

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Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M