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It may increase the proliferative response of T cells, inhibit NLRP3 inflammatory pathway (IL1B and IL18) and decrease plasma TNF [55] According to Zhou et al [56] NAC decreases IBF-alpha, IL-1b, IL-6, IL-8, IL-10, IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, and may also diminish the potency of the cytokine storm, thereby attenuating the detrimental effects of SARS-Cov-2 on multi-system organ failure