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Through gene expression modulation, dietary vitamin E can decrease c-myc and transform growth factor-alpha expression, leading to decreased nitric oxide synthase (iNOS) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which are major contributors to oxidative stress [13,14]

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To our knowledge, this is the first study evaluating the irritancy potential of different types of copper compounds at the cellular, genomic and proteomic levels using keratinocyte cell lines